MK-677

★ 78

MK-677 (Ibutamoren / Nutrobal)

Oral GH secretagogue — no injections

Muscle Growth

Half-life

~24 hours (oral)

Route

Oral

Cycle

8-24 week cycles,

Status

Phase 2 trials at Merck

About

A non-peptide ghrelin receptor agonist in pill form. Raises GH and IGF-1 for 12-24 hours. Popular for those who want GH-related benefits without injections.

Mechanism

Activates ghrelin (GHS-R1a) receptors in the pituitary, triggering a GH pulse similar to hexarelin.

Dosage

beginner

Amount: 10 mg
Frequency: 1x per day (before sleep)
Route: Oral
Duration: 8-12 weeks

standard

Amount: 15-20 mg
Frequency: 1x per day (before sleep)
Route: Oral
Duration: 12-16 weeks

advanced

Amount: 25 mg
Frequency: 1x per day or split in 2
Route: Oral
Duration: 16-24 weeks

Timing

Best before sleep — the GH pulse aligns with the natural nocturnal pulse.

Cycle structure

8-24 week cycles, with 4-8 week breaks (to avoid insulin resistance).

Reconstitution & Storage

Oral (no reconstitution) + Not applicable → Not applicable

MK-677 comes as capsules or a liquid suspension. The syringe visualizer does not apply.

Room temperature, protected from light and moisture.

Benefits

• Raises GH and IGF-1 for 24 hours
• Improved sleep depth
• Increased appetite and muscle mass
• Improved skin and hair
• No injections required

Side effects

• Strong appetite (may be a downside)
• Water retention
• Elevated blood glucose — insulin resistance risk
• Lethargy and fatigue in the first weeks
• Elevated prolactin

Contraindications

• Diabetes or pre-diabetes
• Active cancer
• Heart failure (water retention)
• Pregnancy and breastfeeding

Gender notes

Men

Same dose. Popular for bulking.

Women

Lower dose (10-15 mg) is often enough. Watch for water retention.

Research

Nass et al: MK-677 in older adults ↗
12-month MK-677 in older adults — sustained GH/IGF-1 elevation.

Annals of Internal Medicine · 2008

Stacks well with

SERMORELIN CJC-1295

Track MK-677 doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.