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Semaglutide

★ 98 FDA approved

Semaglutide (Ozempic, Wegovy)

GLP-1 agonist — weight loss and glycemic control

Fat Loss
Half-life
~7 days
Route
SubQ
Cycle
Not cycled —
Status
FDA approved (Wegovy 2021 for obesity)

About

A GLP-1 receptor agonist, FDA-approved for type 2 diabetes and obesity. One of the most effective weight-loss medications available.

Mechanism

Mimics GLP-1, increases insulin, suppresses glucagon, slows gastric emptying, reduces appetite.

Dosage

beginner

Amount
0.25 mg
Frequency
1x per week for 4 weeks
Route
SubQ
Duration
Titration phase

standard

Amount
0.5 mg → 1.0 mg → 1.7 mg
Frequency
1x per week, increasing every 4 weeks
Route
SubQ
Duration
16+ weeks

advanced

Amount
2.4 mg (max dose)
Frequency
1x per week
Route
SubQ
Duration
Long-term (12+ months)
Timing

Same day each week. Timing relative to meals matters little.

Cycle structure

Not cycled — long-term use. Taper gradually if discontinuing.

Reconstitution & Storage

5 mg + 2 mL → 2.5 mg/mL

Store refrigerated after reconstitution, 30 days.

Prescription product: refrigerated. Compounded: 2-8°C, 30-56 days after reconstitution.

Benefits

  • • 15-20% weight loss (STEP trials)
  • • Improved glycemic control
  • • Lowered HbA1c
  • • Reduced cardiovascular risk (SELECT trial)
  • • Reduces appetite and 'food noise'

Side effects

  • • Nausea (common initially)
  • • Diarrhea / constipation
  • • Reflux
  • • Fatigue
  • • Rare: gallstones, pancreatitis

Contraindications

  • • Medullary thyroid carcinoma (history)
  • • MEN 2 syndrome
  • • Pregnancy
  • • History of pancreatitis

Gender notes

Men

Same dose, same efficacy.

Women

Same dose. Discontinue at least 2 months before pregnancy. May reduce oral contraceptive efficacy.

Research

Stacks well with

BPC-157 IPAMORELIN

Track Semaglutide doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

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Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.