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Semax

★ 75

Semax (ACTH 4-10 analog)

Focus and memory

Cognitive
Half-life
Short (minutes), but effects last 24 hours
Route
Intranasal
Cycle
4-8 weeks on,
Status
Approved in Russia for stroke and cognitive symptoms

About

A Russian nootropic peptide, analog of ACTH(4-10). Increases BDNF and NGF.

Mechanism

Increases BDNF (Brain-Derived Neurotrophic Factor) and NGF. Modulates dopamine and serotonin.

Dosage

beginner

Amount
250-500 mcg
Frequency
1-2x per day (nasal)
Route
Intranasal
Duration
4-6 weeks

standard

Amount
600-900 mcg
Frequency
2-3x per day (nasal)
Route
Intranasal
Duration
4-8 weeks

advanced

Amount
1200-1800 mcg (0.1% solution)
Frequency
Split into 2-3 doses
Route
Intranasal or SubQ
Duration
6-8 weeks
Timing

Morning and afternoon. Not too late — can cause sleep problems.

Cycle structure

4-8 weeks on, 2 weeks off.

Reconstitution & Storage

20 mg + 2 mL → 10000 mcg/mL

Most often used as a nasal spray.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 2 mL, with the units to draw for a typical 500–1000 mcg dose.

Semax reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial BAC water Concentration Units to draw
20 mg 2 mL 10000 mcg/mL 5–10 units
30 mg 2 mL 15000 mcg/mL 3.5–6.5 units

Open Semax in the reconstitution calculator →

Lyophilized: freezer. Reconstituted: 2-8°C, 14 days.

Benefits

  • • Improved focus and concentration
  • • Faster memory and processing
  • • Neuroprotection
  • • Improved mood
  • • No crash after use
  • • Supports nerve repair

Side effects

  • • Very well tolerated
  • • Rare: overstimulation if dosed too late
  • • Nasal irritation

Contraindications

  • • Pregnancy
  • • Psychiatric disorders (caution)
  • • Hypertension (mild interaction)

Gender notes

Men

Same dose. Popular for cognitively demanding work.

Women

Same dose. Helps with brain fog in menopause and postpartum.

Research

Stacks well with

SELANK DSIP BPC-157

Semax FAQ

How do you reconstitute Semax?

Add 2 mL of bacteriostatic water to a 20 mg vial of Semax, which gives a concentration of 10000 mcg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical Semax dose?

A typical research dose of Semax is 500–1000 mcg, 2-3x per day (nasal). This is educational information, not medical advice.

How many units of Semax do I draw?

From a 20 mg vial reconstituted with 2 mL of bacteriostatic water, draw 5–10 units on a U-100 insulin syringe for a 500–1000 mcg dose.

Track Semax doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.