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Tirzepatide

★ 96 FDA approved

Tirzepatide (Mounjaro, Zepbound)

Dual GLP-1/GIP agonist — stronger than Semaglutide

Fat Loss
Half-life
~5 days
Route
SubQ
Cycle
Not cycled. Long-term
Status
FDA approved (Mounjaro 2022

About

A dual agonist that activates both GLP-1 and GIP receptors. FDA approved 2022. Shows 20-22% weight loss in clinical trials.

Mechanism

Activates both GLP-1 and GIP, producing synergistic effects on glycemic control, insulin sensitivity, and adipose-tissue regulation.

Dosage

beginner

Amount
2.5 mg
Frequency
1x per week for 4 weeks
Route
SubQ
Duration
Titration phase

standard

Amount
5 mg → 7.5 mg → 10 mg
Frequency
1x per week, increasing every 4 weeks
Route
SubQ
Duration
16-20 weeks

advanced

Amount
12.5 mg → 15 mg (max)
Frequency
1x per week
Route
SubQ
Duration
Long-term
Timing

Same day each week. Any time of day, with or without food.

Cycle structure

Not cycled. Long-term use with taper if discontinuing.

Reconstitution & Storage

10 mg + 3 mL → 3.33 mg/mL

Compounded version. Prescription pen is pre-filled.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 3 mL, with the units to draw for a typical 2.5–15 mg dose.

Tirzepatide reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial BAC water Concentration Units to draw
10 mg 3 mL 3.33 mg/mL 75–450 units
20 mg 3 mL 6.67 mg/mL 37.5–225 units
30 mg 3 mL 10 mg/mL 25–150 units
40 mg 3 mL 13.33 mg/mL 19–112.5 units
60 mg 3 mL 20 mg/mL 12.5–75 units

Open Tirzepatide in the reconstitution calculator →

Refrigerated 2-8°C. Compounded: 30-56 days after reconstitution.

Benefits

  • • 20-22% weight loss (SURMOUNT trials)
  • • Stronger effects than Semaglutide (head-to-head trial)
  • • Improved glycemic control
  • • Lowered blood pressure
  • • Improved lipid profile

Side effects

  • • Nausea (common initially)
  • • Diarrhea
  • • Reflux
  • • Constipation
  • • Abdominal pain

Contraindications

  • • Medullary thyroid carcinoma
  • • MEN 2 syndrome
  • • Pregnancy
  • • History of pancreatitis
  • • Severe gastrointestinal disease

Gender notes

Men

Same dose. Sometimes more pronounced weight loss than in women.

Women

Same dose. May reduce oral contraceptive efficacy (use backup contraception for the first 4 weeks after each dose increase).

Research

Stacks well with

BPC-157 IPAMORELIN

Tirzepatide FAQ

How do you reconstitute Tirzepatide?

Add 3 mL of bacteriostatic water to a 10 mg vial of Tirzepatide, which gives a concentration of 3.33 mg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical Tirzepatide dose?

A typical research dose of Tirzepatide is 2.5–15 mg, 1x per week, increasing every 4 weeks. This is educational information, not medical advice.

How many units of Tirzepatide do I draw?

From a 10 mg vial reconstituted with 3 mL of bacteriostatic water, draw 75–450 units on a U-100 insulin syringe for a 2.5–15 mg dose.

Track Tirzepatide doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.