MOTS-c
★ 78Mitochondrial-derived peptide MOTS-c
Mitochondrial peptide — metabolic switch
LongevityAbout
A naturally occurring peptide encoded by mitochondrial DNA. Increases AMPK activity, improves glucose tolerance and metabolic flexibility.
Mechanism
Activates the AMPK pathway, promoting fat oxidation, glucose utilization, and mitochondrial health.
Dosage
beginner
- Amount
- 5 mg
- Frequency
- 3x per week
- Route
- SubQ
- Duration
- 4-6 weeks
standard
- Amount
- 10 mg
- Frequency
- 3x per week
- Route
- SubQ
- Duration
- 6-8 weeks
advanced
- Amount
- 10-15 mg
- Frequency
- 3-5x per week
- Route
- SubQ
- Duration
- 8-12 weeks with a 4-week break
Pre-workout or in the morning on an empty stomach.
6-12 weeks on, 4 weeks off.
Reconstitution & Storage
Relatively expensive — measure precisely.
Lyophilized: freezer. Reconstituted: 2-8°C, 14 days.
Benefits
- • Improved mitochondrial function
- • Increased insulin sensitivity
- • Fat loss
- • Improved energy
- • Slower aging (animal data)
- • Improved athletic performance
Side effects
- • Generally very well tolerated
- • Rare: mild fatigue at first
Contraindications
- • Pregnancy (no research)
- • Type 1 diabetes (caution — monitor blood glucose)
Gender notes
Men
Same dose. Popular for performance.
Women
Same dose. Especially useful in menopause (metabolic slowdown).
Research
- Lee C et al: MOTS-c regulates insulin sensitivity ↗
Landmark study that defined MOTS-c and its activity.
Cell Metabolism · 2015
- Reynolds JC et al: MOTS-c improves muscle insulin sensitivity ↗
MOTS-c improves muscle metabolic health and endurance performance in mice.
Nature Communications · 2021
Stacks well with
Track MOTS-c doses in the app
Built-in reconstitution calculator, dose log, and reminders. Free on Android.
Get on Google PlayEducational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.