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Retatrutide

★ 88

Retatrutide (LY3437943)

Triple GLP-1/GIP/glucagon agonist

Fat Loss
Half-life
~6 days (SubQ)
Route
Subcutaneous (SubQ)
Cycle
No structured break
Status
Phase 3 (TRIUMPH program 2024-2025)

About

Eli Lilly's triple-agonist peptide that activates GLP-1, GIP and glucagon receptors simultaneously. Phase 3 trials show 24%+ weight loss after 48 weeks — the largest weight loss seen with any GLP-1-class drug to date.

Mechanism

Triple activation: GLP-1 (appetite suppression + insulin), GIP (insulin sensitivity), glucagon (energy expenditure and lipolysis).

Dosage

beginner

Amount
2 mg
Frequency
1x per week (4-week titration)
Route
Subcutaneous (SubQ)
Duration
Long-term

standard

Amount
4 mg → 8 mg
Frequency
1x per week (increase every 4 weeks)
Route
Subcutaneous (SubQ)
Duration
Long-term

advanced

Amount
12 mg (max)
Frequency
1x per week
Route
Subcutaneous (SubQ)
Duration
Long-term
Timing

Same weekday each week, independent of meals. Best in the morning or evening.

Cycle structure

No structured break — long-term maintenance like semaglutide.

Reconstitution & Storage

10 mg + 1 mL → 10 mg/mL

Can be stored refrigerated after reconstitution for up to 4 weeks.

Dosing reference — units to draw

Concentration = peptide mass ÷ bacteriostatic water; units to draw = dose volume (mL) × 100 on a U-100 insulin syringe. Each vial size below is shown at 1 mL, with the units to draw for a typical 2–12 mg dose.

Retatrutide reconstitution: vial size, bacteriostatic water, resulting concentration, and units to draw on a U-100 insulin syringe for a typical dose.
Vial BAC water Concentration Units to draw
10 mg 1 mL 10 mg/mL 20–120 units
12 mg 1 mL 12 mg/mL 16.5–100 units
24 mg 1 mL 24 mg/mL 8.5–50 units

Open Retatrutide in the reconstitution calculator →

Lyophilized: refrigerated 2-8°C. After reconstitution: 2-8°C, 28 days.

Benefits

  • • Largest weight loss among GLP-1 class drugs
  • • Improved glycemic control
  • • Increased energy expenditure
  • • Cardioprotective effects (preliminary)

Side effects

  • • Nausea and vomiting (common initially)
  • • Diarrhea and constipation
  • • Headache
  • • Possible pancreatitis (rare)

Contraindications

  • • Pregnancy and breastfeeding
  • • History of pancreatitis
  • • Medullary thyroid carcinoma (MEN2)
  • • Severe gastroparesis

Gender notes

Men

Same dose as general protocol. Popular for metabolic syndrome.

Women

Same dose. Check fertility plans before starting.

Research

Stacks well with

MOTS-C TESAMORELIN

Retatrutide FAQ

How do you reconstitute Retatrutide?

Add 1 mL of bacteriostatic water to a 10 mg vial of Retatrutide, which gives a concentration of 10 mg/mL. Inject the water slowly down the vial wall and swirl gently — never shake.

What is a typical Retatrutide dose?

A typical research dose of Retatrutide is 2–12 mg, 1x per week (increase every 4 weeks). This is educational information, not medical advice.

How many units of Retatrutide do I draw?

From a 10 mg vial reconstituted with 1 mL of bacteriostatic water, draw 20–120 units on a U-100 insulin syringe for a 2–12 mg dose.

Track Retatrutide doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.