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Retatrutide

★ 88

Retatrutide (LY3437943)

Triple GLP-1/GIP/glucagon agonist

Fat Loss
Half-life
~6 days (SubQ)
Route
Subcutaneous (SubQ)
Cycle
No structured break
Status
Phase 3 (TRIUMPH program 2024-2025)

About

Eli Lilly's triple-agonist peptide that activates GLP-1, GIP and glucagon receptors simultaneously. Phase 3 trials show 24%+ weight loss after 48 weeks — the largest weight loss seen with any GLP-1-class drug to date.

Mechanism

Triple activation: GLP-1 (appetite suppression + insulin), GIP (insulin sensitivity), glucagon (energy expenditure and lipolysis).

Dosage

beginner

Amount
2 mg
Frequency
1x per week (4-week titration)
Route
Subcutaneous (SubQ)
Duration
Long-term

standard

Amount
4 mg → 8 mg
Frequency
1x per week (increase every 4 weeks)
Route
Subcutaneous (SubQ)
Duration
Long-term

advanced

Amount
12 mg (max)
Frequency
1x per week
Route
Subcutaneous (SubQ)
Duration
Long-term
Timing

Same weekday each week, independent of meals. Best in the morning or evening.

Cycle structure

No structured break — long-term maintenance like semaglutide.

Reconstitution & Storage

8 mg + 2 mL → 4 mg/mL

Can be stored refrigerated after reconstitution for up to 4 weeks.

Lyophilized: refrigerated 2-8°C. After reconstitution: 2-8°C, 28 days.

Benefits

  • • Largest weight loss among GLP-1 class drugs
  • • Improved glycemic control
  • • Increased energy expenditure
  • • Cardioprotective effects (preliminary)

Side effects

  • • Nausea and vomiting (common initially)
  • • Diarrhea and constipation
  • • Headache
  • • Possible pancreatitis (rare)

Contraindications

  • • Pregnancy and breastfeeding
  • • History of pancreatitis
  • • Medullary thyroid carcinoma (MEN2)
  • • Severe gastroparesis

Gender notes

Men

Same dose as general protocol. Popular for metabolic syndrome.

Women

Same dose. Check fertility plans before starting.

Research

Stacks well with

MOTS-C TESAMORELIN

Track Retatrutide doses in the app

Built-in reconstitution calculator, dose log, and reminders. Free on Android.

Get on Google Play

Educational use only. Not medical advice. Many peptides shown are not FDA-approved and remain research compounds. Always consult a qualified healthcare provider.